MSA CenterS of excellence
Publications
Our Centers of Excellence are at the heart of MSA research, conducting studies that shape the future of diagnosis, care, and treatment. This work represents the dedication of scientists, clinicians, and patients working together to change the future of MSA.
Proximity proteomics reveals unique and shared pathological features between multiple system atrophy and Parkinson’s disease
Both Parkinson’s disease and MSA demonstrate accumulation of the same abnormal protein, alpha-synuclein in the brain. This paper explores the similarities and differences in the parts of the brain that demonstrate the accumulation of the abnormal protein.
MSA Center of Excellence:
Prodromal, established, and advanced Parkinson’s disease and atypical parkinsonisms: Prevalence and healthcare service utilization in the Catalan Health Surveillance System (Catpark study)
MSA Center of Excellence:
Pain in Multiple System Atrophy – A Community Based Survey
This study’s aim was to assess the prevalence, characteristics, and current treatment strategies for pain in MSA.
MSA Center of Excellence:
Oligodendrocyte-specific overexpression of human alpha-synuclein results in elevated MBP levels and inflammatory responses in TgM83 mice, mimicking the pathological features of multiple system atrophy
These findings suggest that hSNCA overexpression is associated with increased myelin basic protein levels and enhanced inflammatory responses, implicating that myelin basic protein and myelination processes may play previously underappreciated roles in the pathogenesis of MSA.
MSA Center of Excellence:
Multiple System Atrophy: Pathology, Pathogenesis, and Path Forward
Multiple system atrophy (MSA) is a rare but fatal brain disease that causes problems with movement and automatic body functions, like blood pressure control. Scientists have found that MSA involves a unique buildup of a protein called α-synuclein, and they are exploring whether changes in brain cells or the immune system may be the main cause, with new research bringing hope for better understanding and future treatments.
MSA Center of Excellence: